| Quality Level | 200 |
|---|---|
| Assay | ≥95% (HPLC) |
| Form | powder |
| Color | white to yellow |
| Mp | 150-160 °C (dec.) (lit.) |
| Solubility | ethanol: 50 mg/mL |
Description
Colchicine is a secondary metabolite,[2] which has anti-inflammatory properties.[1] It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines.[1] It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space