Senna glycosides or sennosides are a number of anthraquinone derivatives useful as a laxative. They are dimeric glycosides named after their abundant occurrence in plants of the genus Tinnevelly senna (Cassia angustifolia Vahl). Senna contains mainly two anthraquinone glycosides such as sennoside A and sennoside B and small quantities of other anthraquinones such as sennosides C and D, rhein 8-glucoside, rhein-8-diglucoside, aloe-emodin, 8-glucoside, anthrone diglucoside and rhein. It also consists of two naphthalene glycosides namely Tinnevellin glycoside and 6-hydroxy musizin Glycoside.
Senna is known for its purgative action. The phytoconstituents principally responsible for its characteristic action is sennoside A and sennoside B. Sennoside A and B together are responsible for up to 40 – 60% activity of crude senna. These glycosides increase secretion of gastric fluids and affect colonic motility and hence, facilitate colonic transit. These phytocontituents remain unabsorbed in the upper intestinal tract. They are activated by large intestine bacteria into the active derivatives (rhein-anthrone).
Sennosides are used for the short term treatment of symptomatic constipation. It may also be used to aid in the evacuation of the bowel prior to surgery or invasive rectal or colonic examinations.
The product addresses broad spectrum physiological concerns and has the band width and capabilities to meet expectations. Regular use should exhibit demonstrable results to inhibit various health related issues.